pentobarbital will lessen the level or outcome of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Solid or moderate CYP3A4 inducers might maximize charge of diazepam elimination; hence, efficacy of diazepam could possibly be decreased.

pentobarbital will lessen the level or effect of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is usually a delicate CYP3A4 substrate. Coadministration with robust or moderate CYP3A4 inducers is contraindicated.

Keep track of Carefully (1)pentobarbital will lessen the level or result of benzhydrocodone/acetaminophen by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Warning when discontinuing CYP3A4 inducers which have been coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone may possibly maximize and may end up in most likely lethal respiratory depression.

pentobarbital will reduce the level or result of finasteride by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unidentified.

pentobarbital will lessen the level or impact of irinotecan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.

pentobarbital will lessen the level or influence of darunavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

benzhydrocodone/acetaminophen and pentobarbital each improve sedation. Steer clear of or Use Alternate Drug. Limit use to people for whom alternate cure choices are inadequate

pentobarbital will lessen the level or outcome of methadone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.

pentobarbital will lessen the extent or outcome of piroxicam by influencing hepatic enzyme CYP2C9/ten metabolism. Insignificant/Importance Unknown.

pentobarbital decreases effects of hemin by pharmacodynamic antagonism. Use Caution/Watch. Drugs that enhance delta-aminolevulinic acid synthetase may lessen hemin impact.

pentobarbital will lower the extent or influence of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.

pentobarbital will minimize the level or effect of ambrisentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Mysterious.

pentobarbital will lessen the level or impact of lumacaftor/ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

With therapeutic check here doses of TCAs, barbiturates maximize metabolism and decrease blood concentrations of TCAs.